This text for advanced undergraduate and graduate students covers the fundamental relationships between the structure and properties of materials and biological tissues. The ultimate aim of a biomaterials scientist is to successfully integrate material and biological properties, shape, and architecture to engineering a wide range of optimized designs for specific functions. Relevant examples illustrate the intrinsic and tailored properties of metal, ceramic, polymeric, carbon-derived, composite, and naturally derived biomaterials. Fundamentals of Biomaterials is written in a single voice, ensuring clarity and continuity of the text and content. As a result, the reader will be gradually familiarized with the field, starting with materials and their properties and eventually leading to critical interactions with the host environment. Classic and novel examples illuminate basic material properties, tissue engineering, nanomaterials, and guided tissue regeneration. This comprehensive and engaging text: integrates materials and biological properties to understand biomaterials function, and design provides the basics of biological tissue components. The hierarchy includes recent topics from tissue engineering and guided tissue regeneration to nanoarchitecture of biomaterials. Their surfaces contain perspectives/case studies from widely-recognized experts in the field feature chapter-ending summaries to help readers identify the key, take-home messages.